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KMID : 0614020000160010070
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Journal of Pharmaceutical Sciences (C.N.U.)
2000 Volume.16 No. 1 p.70 ~ p.77
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Lymphoblastogenic Activity of 10 Korean Basidiomycetes including Geastrum fimbriatum and Clitocybe candicans
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Kim Hyun-Jin
Lee Ji-Seon
Chung Kyeong-Soo
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Abstract
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As an effort to find out potent antitumor immunomodulatory agents from Korean basidiomycetes, the protein-polysaccharide fractions were prepared from ten mushrooms - Pleurotus ostreatus, Agaricus bisporus, flammulina velutipes, Lentius edodes, Macrolepiota procera and Coriolus versicolor - and subjected to a flow cytometrical analysis for their lymphoblastogenic activity on the in vitro cultured mouse splenic lymphocytes. As a result, Geastrum fimbriatum and Clitocybe candicans showed remarkable lymphoblastogenic effect, the maximum stimulatory index of them being 3.73 and 2.52, respectively, whereas the others showed minimal effects.
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KEYWORD
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Basidiomycetes, protein-polysaccharide, immunomodulatory agent, Clitocybe candicans, Geastrum fimbriatum, flow cytometry, lymphoblast
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